Magnesium threonate relieves depression and anxiety

The effect of L magnesium threonate is more effective in increasing the magnesium content in CSF.

In animal models, only magnesium L threonate, not magnesium chloride or magnesium gluconate, increased magnesium levels in cerebrospinal fluid and improved cognitive performance.

A report on magnesium's role in improving mood was published in 1921 and showed that 220 of 250 cases were successful. Since then, numerous case reports have found that magnesium supplements can quickly improve mood with no side effects. In addition:

A randomized peer-to-peer trial found that oral magnesium supplements were just as effective as antidepressants in improving mood.

Therefore, clinical studies in humans have shown that magnesium supplements can help improve mood. About 60 percent of people with mood depression are considered difficult to treat, possibly due to magnesium deficiency. In addition:

For people who are depressed but do not respond to medication, low magnesium levels may be associated with poor treatment.

The higher the magnesium intake, the higher the scores on mood tests.

All of this points to the potential role of magnesium, particularly L threonate, in emotional health.

Overall, depression may just be a sign of magnesium deficiency in the brain. Optimizing magnesium levels in the brain, particularly through the use of magnesium L threonate, could have profound effects on mood.

Importantly, magnesium is needed to make the three main neurotransmitters in the brain (serotonin, dopamine and norepinephrine) and melatonin (which is essential for sleep).

L Magnesium threonate improves anxiety

Higher stress levels can lead to magnesium deficiency by increasing the amount of magnesium lost through urine.

In addition, magnesium deficiency can increase the stress response.

Magnesium deficiency increases stress-induced mortality in animals, and effective correction of magnesium deficiency improves the nervous system's ability to resist stress.

In other words, stress causes magnesium deficiency, which in turn causes stress.

Animals on a low-magnesium diet showed more anxiety-related behaviors, possibly due to high brain excitability and increased cortisol production.

Importantly, two studies have shown that supplementing animals with magnesium L threonate can reduce anxiety.

Thus, magnesium threonate may play a central role in relieving anxiety. In short, anxiety can lead to magnesium deficiency, and vice versa. Given that most people in the United States don't get enough magnesium through their diets, supplementation with magnesium L threonate may have an important role in reducing anxiety